How to Create a Drupal Multisite? In multisite, I create separate folders under /sites for each domain, configure individual settings.php with separate databases, and install Drupal per site while reusing the same codebase. Ex : sites/site.domain1/settings.php sites/site.domain2/settings.php In multisite, even though the codebase is shared, module enablement is stored in each site's configuration. So enable the module only on the required site via admin or drush, and it remains disabled on other sites because they have separate databases. Then you must maintain separate config sync folders per site . $config_directories['sync'] = '../config/site1'; In multisite, apart from settings.php, we use services.yml for service overrides, separate files directories for uploads, private file paths, and most importantly separate config sync directories to isolate configuration per site.